Based on a presentation by Dr Karl Bates (UoL Institute of Ageing and Chronic Disease):
“Biomechanics – understanding the relationship between anatomy and function”
Happy Sunday, everyone! Hope you’re having a good weekend! Here we have a description of the 2nd piece of research presented at the evening of seminars I attended last week. Enjoy!
Now, the first thing you might be wondering after reading the title is, what exactly is the field of Biomechanics? I’ll admit that I’d never heard of it before this talk! Essentially, it’s the study of an organism’s moving parts in order to understand how their arrangement relates to their function. Dr Bates’ research group is looking at human legs, studying the relationship between their morphology (i.e. the shape and arrangement of muscles, bones and tendons etc) and the way humans walk.
The group wants to find the muscle activation pattern that produces the fastest, or most energy-efficient, way of running. They’re carrying out their work using a technology called ‘Evolutionary Robotics’. This involves a computer program that uses a mathematical model (code for ‘maths 99% of us can’t hope to grasp’!) with values for every single muscle in the pair of legs.
The system takes recordings of a human running through the group’s ‘gait lab’ and matches the pattern of muscle activation it sees. It then tests every possible combination of muscle contraction strengths and timings as it attempts to create the most energy-efficient version of the running motion it saw.
Sounds relatively straightforward – leave your computer running for a while and let it come back with a neat and tidy result, right? Well….no. There are millions and millions of possible combinations that the computer needs to work through. As such, they need one impressively powerful computer, and it still takes ages!
Brilliantly, the program builds a pair of virtual human legs, including tissues, joints and tendons, so you can see how its current optimum equation works. At this point, Dr Bates showed us a ridiculous video of a pattern the computer suggested early on. The legs rotated round the hips in 360° turns, moving along like some kind of grotesque ball! One of the latest suggestions shows the legs moving normally for a while…before falling over! But it is getting there…
Now, this is all well and good, but what’s the point? Well, once the computer program has mastered the leg movement, the group can use it to understand the changes humans undergo as we age. We know that we lose muscle mass and gain fat, meaning that our bodies can’t operate in exactly the same way as when we were young. But what we don’t know is in what ways our bodies have to compensate for these changes.
Dr Bates said that, once they know how the legs move and which muscles are needed, they can start playing around with the anatomy in a way they couldn’t do in real life. They can, for example, change tendon lengths and muscle masses in a virtual pair of legs to reflect an older person’s physiology. This will allow them to see how energy efficiency changes during a person’s life-time and how different parts of the legs must change to cope with, for example, reduced muscle mass. This will give us a greater understanding of the pressures our bodies come under as they age.
The group’s work will also help us understand more about how we have evolved as a species. A really interesting application of the group’s work so far has been to solve the controversy over how one of our ancient ancestors – Australopithecus afarensis – walked. The best-known fossil of the species is a partial skeleton, which has been named Lucy!
Lucy is 3.2 million years young and, despite how little of her was found, researchers have estimated that the lengths of Lucy’s humerus and femur leg bones are right in-between the lengths seen in humans and chimps. So, the question is, did she walk upright like humans or using her arms like chimps?
The group used their computer program to simulate Lucy walking in both ways. They worked out that it was far more energy-efficient for her to walk upright, given her bone structure. As animals very often adapt to be more energy-efficient, it seems likely that Lucy and her Australopithecus afarensis brethren walked upright like us.
To confirm this, the group compared the heel pressure Lucy was predicted to exert when walking upright with the pressure her preserved footprint implied. The two pieces of evidence matched. So, thanks to this research and the group’s remarkably clever computer software, we now know that 3.2 million years ago our ancestors were already walking upright. This suggests that we started walking upright when we were still living in the trees rather than when we’d moved down to the ground, as we previously thought!
I think this is a fascinating piece of research and the findings and potential applications are incredible, offering compelling evidence for how our ancestors have evolved. I look forward to hearing more about the group’s findings as their research continues.
Next up in this mini-series, we have a description of how ‘Personalised Medicine’ will work and how far away it is from being a reality. Come back next week for that one. Till then, have a great few days!
- Why Humans’ Ancestors Began Walking Upright (voanews.com)